When the Howard Hughes Foundation decided it would fund a premier medical research facility it was only logical that it be located on the campus of the National Institute of Health. To be known as the Howard Hughes Medical Institute, the old Cloisters Building was chosen to be the centerpiece for the new facility. J. Vinton Schafer & Sons, Inc. was chosen to be the constructor.

The historic structure was renovated and refurbished inside and out. A new matching structure was constructed a short distance from the old building and connected with a precast and glass lobby/reception area.

This facility had to be state-of-the-art and offer all of the amenities to attract the "best of the best" medical researchers. The laboratories, classrooms, offices and residences all met this requirement. The Howard Hughes Medical Institute is truly a world class research facility located on a world class campus.